Showing posts with label Food Allergy. Show all posts
Showing posts with label Food Allergy. Show all posts

Tuesday, March 31, 2015

This British study may change the views on peanut allergy forever!



  • Striking new evidence shows that feeding peanuts to high-risk children in their first year of life can reduce the likelihood of peanut allergy years later by up to 80 percent.

    Dr. Hugh Sampson, past president of the American Academy of Allergy, Asthma and Immunology recently wrote in an editorial: “We believe the results from this trial are so compelling, and the problem of the increasing peanut allergy so alarming, that new guidelines should be forthcoming very soon”.


    Over the past years, Dr. Sampson has published many articles on food allergy. But here he is referring to the LEAP (Learning Early About Peanut Allergy) study. It was published in the New England Journal of Medicine last month, and led by George Du Toit, M.B., B.Ch. (see links below.)


    This study included 640 children between the ages of 4-11 months who were high-risk for development of peanut allergy. High-risk was defined, in this study, as having a history of severe eczema, egg allergy or both. The children were divided into one group that would be regularly fed peanut snacks, and another that would be restricted from peanuts. They were monitored for five years.

    The investigators began the study by dividng the children into two groups based on the results of a peanut allergy skin-test. Only the children that tested negative for peanut were divided into those that would either be given or restricted panuts for the study. Those who skin-tested or orally tested positive were immediately removed from the study. However, researchers kept children who showed a slight peanut allergy. These included those who skin-tested positive to peanut, but didn't react to an oral allergy test. 

    The results of the study were described as astonishing. At 5 years of age, only 3 percent of the children getting peanuts were found to be allergic to them, but 17 percent of the peanut avoidance group became peanut-allergic. Furthermore, the skin-test positive children were far less peanut-allergic at age 5 if they had been exposed to peanut snacks (10.6 percent if fed peanuts versus 35 percent if restricted). The overall percentage of peanut allergy in the country was 2 percent (the study included only high-risk children).

    Up until 2008, allergists advised parents of high-risk children to restrict their young from peanuts and tree nuts until school age. Based on developments over the last decade, and highlighted by this study, the opposite is true.

    What does this mean?

    National guidelines for prevention of peanut allergy will change in oncoming months. They will likely recommend early peanut testing of high-risk infants and consultation with allergists.


    Unanswered Questions Include:

    • How long does peanut tolerance last once achieved?
    • Do children need to continue to eat peanut products three times weekly in order to maintain tolerance (as done in the study)? How much peanut snack needs to be consumed? 
    • What happens if there is an interruption in peanut consumption during the first several months or years?
    • What if the infants don’t want to eat peanut butter snacks? Feeding them peanuts won’t be an option because of the risk of choking.
    • Wouldn’t early introduction of peanuts place other peanut allergic members of the family at risk for accidental exposure? 
    • What can we do about young children already allergic to peanut? 
    • Would this work for other food allergies?

  • Bottom Line:

    The Leap study is truly a game changer, but only for high-risk children under one year of age. In this group the results showed a 70 to 80 percent reduction in the development of peanut allergy. Health experts in the U.S. will further review these findings and make appropriate recommendations to allergists, pediatricians and other primary care doctors, so stay tuned!


    It is important to understand that conclusions in this study are to be reviewed and utilized by physicians to manage patients. Parents should not expose their infants to peanut if they are at increased risk, before discussing it with their doctor.


    References:



  • Monday, March 30, 2015

    Green areas around homes reduce atopic sensitization in children!!!

    Green areas around homes reduce atopic sensitization in children

    Western lifestyle is associated with high prevalence of allergy, asthma and other chronic inflammatory disorders. ‘Biodiversity hypothesis’ suggests that reduced contact of children with environmental biodiversity, including environmental microbiota in natural habitats, has adverse consequences on the assembly of human commensal microbiota and its contribution to immune tolerance.

    This study analysed 4 cohorts from Finland and Estonia with 1,000 children and adolescents aged 0.5–20 yrs. The prevalence of atopic sensitization was assessed by measuring serum IgE specific to inhalant allergens. WProportion of 5 land-use types—forest, agricultural land, built areas, wetlands, and water bodies—in the landscape around the homes was calculated using the CORINE2006 classification.

    The cover of forest and agricultural land within 2–5 km from the home was inversely associated with atopic sensitization. This relationship was observed for children 6 years of age and older.

    Land-use pattern explained 20% of the variation in the relative abundance of Proteobacteria on the skin of healthy individuals, supporting the hypothesis of a strong environmental effect on the commensal microbiota.

    The amount of green environment (forest and agricultural land) around home was inversely associated with the risk of atopic sensitization in children. Early life exposure to green environments is especially important. The environmental effect may be mediated via the effect of environmental microbiota on the commensal microbiota influencing immunotolerance.

    References:

    Green areas around homes reduce atopic sensitization in children. Lasse Ruokolainen et al. Allergy, 2014, DOI: 10.1111/all.12545.
    http://onlinelibrary.wiley.com/doi/10.1111/all.12545/abstract

    Take care of your Asthma

    Here was this season of Diwali and our Asthmatic friends really passed a tough time.
    So here's this a comprehensive guideline for your care if you are an asthmatic.

    A Patient's Guide to Asthma Care


    IS YOUR ASTHMA WELL-CONTROLLED?

    If you need your quick relief (Reliever) medication as little as four times per week (not counting use for prevention of exercise-induced asthma), your asthma is probably not well-controlled.
    This may sound surprising, even shocking, but it's true. Up to 85% of people with asthma can live virtually symptom-free, or well-controlled, needing little or no quick relief at all! Most of the other 15% can be greatly aided by the information in this guide.

    WELL-CONTROLLED SYMPTOMS

    You or your child's asthma is WELL-CONTROLLED if you:
    • have symptoms of coughing, wheezing, or shortness of breath 3 or fewer days per week;
    • can carry out most desired activities, work and play, without having asthma symptoms;
    • wake at night or early in the morning because of your asthma 1 or 0 nights per week;
    • have no sudden, severe or unpredictable flare-ups; and
    • need your quick relief medication 3 or fewer times per week.
    If this describes you, then you have asthma that is well-controlled. As with all asthma, however, you need to monitor your symptoms in case they worsen.

    Signs of Dangerous Asthma

    About 10-15% of asthmatics suffer more seriously from the disease and are at higher risk of having "out of control" asthma.
    IF YOU EVER...
    • get only temporary relief (1 to 4 hours) or none at all after using your quick relief medication or
    • have difficulty speaking normally because of your asthma
    THIS IS AN EMERGENCY....SEE YOUR DOCTOR OR GO TO THE HOSPITAL RIGHT AWAY!

    HOW DO DOCTORS DIAGNOSE ASTHMA?

    Diagnosis of asthma should involve the following steps:
    • assessing symptoms of cough, wheeze, chest tightness and shortness of breath;
    • assessing severity of symptoms; do they
      • occur daytime and/or nighttime?
      • occur with physical activity?
      • occur frequently?
      • lead to missed play/school/work?
    • assessing family history of asthma, allergies;
    • assessing possible allergies to inhalants and/or food; other signs of allergy of the skin, nose and intestine;
    • referral for allergy testing (includes infants);
    • referral for breathing tests.

    LIVING WITH ASTHMA: THE EXPERIENCES OF OTHER PATIENTS

    Allergy/Asthma Information Association (AAIA)
    A national organization devoted to helping fellow asthma, allergy and anaphylaxis sufferers, the Allergy/Asthma Information Association (AAIA) publishes current information medically screened by the Canadian Society of Allergy and Clinical Immunology, holds support groups, provides telephone support and referrals and advocates at national and regional levels.
    Services are available through membership or donations. Call us at 1-800-611-7011 FREE

    HOW DO DOCTORS TREAT ASTHMA?

    Treatment of asthma should involve all of the following steps:
    • controlling symptoms as rapidly as possible by:
      • assessing home/school/work asthma triggers and
      • recommending avoidance; and
      • prescribing medication (steroids, inhaled or — if needed — oral, and a quick relief medication);
    • referral for asthma education;
    • checking inhaler technique;
    • scheduling a follow-up appointment; and
    • providing personalized instructions to keep track of quick relief puffs used per week and an Action Plan of what to do in case of a flare-up.
    At follow-up appointment(s):
    • redoing breathing tests;
    • rechecking inhaler technique;
    • reviewing medication; and
    • providing individualized instructions to keep track of quick relief puffs used per week and reviewing the Action Plan of what to do in case of a flare-up.
    This process of appointments and follow-ups continues until patients and caregivers:
    • know the signs of well-controlled and out-of-control asthma;
    • understand the need to avoid triggers whenever possible;
    • understand the need for anti-inflammatory medication;
    • learn how to adjust their medication quickly at the first signs of a flare-up; and
    • understand that an asthma educator and patient associations can help them learn all of the above.

    How Asthma puts the "Squeeze" on Breathing

    The inflamed lining of the breathing tubes causes the "squeeze" of muscles surrounding them, leading to feelings of chest tightness, shortness of breath, mucus production and coughing.

    WHAT'S HAPPENING IN MY BODY?

     

     

    INFLAMMATION

    Asthma is an immune system overreaction of the lining of the airways — the breathing tubes — in the lungs. If you were to accidentally spill hot liquid onto your hands, or if you could sunburn your airways, they would look scalded and swollen. In asthmatics, this is what the linings of the breathing tubes look like — red, swollen — inflamed.
    The following are the most common airborne triggers which can lead to inflammation and worsening asthma:

    • ALLERGENS, such as house dust mites, animal dander, moulds and cockroaches;
    • COLD VIRUSES and other infections;
    • IRRITANTS, such as cigarette smoke and outdoor air pollution.
    There are many others.

    Irritants

    • Temperature changes (bursts of cold or hot air, or seasons which bring colder or warmer air);
    • Perfumes and colognes; and
    • Strong toxic chemical smells, such as gasoline, marker pens or household cleaners.

    CASCADING SYMPTOMS

    Once the airways are inflamed, a number of asthma symptoms may follow. A scald or burn begins to secrete fluid. Inflamed breathing tubes can secrete mucus which can clog them. But something else can happen, too. Surrounding the breathing tubes, there are bands of muscle whose natural purpose is to contract and relax depending on physical activity. When we breathe into inflamed tissue (which obviously cannot be avoided), the bands of muscle contract more than they would if the airways weren't inflamed. The muscles tense and tighten, squeezing the breathing tubes, so that less air can move in and out. Narrowing of the breathing tubes feels like shortness of breath or breathing discomfort. Finally, a whistling (wheezing) noise as an asthmatic breathes and coughing may follow.

    TRIGGER AVOIDANCE: A CLOSER LOOK AT PREVENTION

    ALLERGENS

    One contact with an allergen can lead to a series of immune system reactions that can go on for days or weeks, re-triggering airway inflammation long after the initial allergic exposure. This is how ongoing allergen exposure leads to ongoing inflammation and asthma. Presently there is no reliable way to calm down this immune system over-response except to prevent or reduce exposure to allergens. Scientifically proven ways to remove or reduce particular allergy triggers that can improve your asthma include:
    • buying dust mite-proof encasings for your pillows and mattresses (including the box spring);
    • removing carpeting from the bedroom of the allergic person;
    • removing carpeting everywhere in the home;
    • keeping household humidity below 50%;
    • removing pets from the home (washing will not reduce allergen levels enough);
    • avoiding outdoor activity in early to late morning during pollen seasons when you are allergic.

    IRRITANTS

    Non-allergic triggers are less persistent in their effect on the immune system. They are considered irritants which, when removed, can lead to relatively rapid alleviation of asthma symptoms. Regular exposure, however, can lead to recurrent, chronic symptoms. Removing or avoiding irritants is generally easier than allergen avoidance. Unnecessary exposure to these should be avoided or eliminated altogether where possible.

    CIGARETTE SMOKE

    Young children have smaller, more delicate airways than adults. When exposed to passive smoke, many children develop sensitive airways, which make them more susceptible to a number of problems, including asthma. Research has shown that children who live with smokers have higher rates of asthma.

    EXERCISE-INDUCED ASTHMA

    Exercise triggers asthma symptoms in almost all asthmatics, mild to severe. Symptoms may be prevented by doing warm-up exercises and using your Reliever inhaler about 15 minutes before activity likely to bring on symptoms.

    INDOOR/ OUTDOOR AIR QUALITY

    Because our energy-efficient homes let less outdoor air in and less indoor air out, indoor allergens, such as house dust mite, animal dander or moulds, can accumulate in indoor air. In effect, we are continuously breathing in higher concentrations of allergens. There is a causal link between indoor air pollution and the onset of asthma.
    Solutions to this problem include:
    • reducing sources of indoor allergens (e.g. carpeting);
    • keeping humidity below 50%;
    • decontaminating mouldy places, such as basements, humidifiers, and bathroom tiles;
    • increasing ventilation throughout the home; and
    • seeking the advice of a professional indoor air quality expert (see resources section).
    Outdoor pollution worsens (but does not cause) asthma symptoms.
    • Exposure should be avoided when ground level ozone concentrations are highest — in late afternoon, especially on very sunny days which contribute to increased smog levels.
    • Observe smog alerts and stay indoors on these days.

    Second-hand Smoke: A contributor to Asthma and Indoor Air Pollution

    • Make your home and car smoke free;
    • Don't smoke or find a program and/or medication to help you stop;
    • Avoid smoky environments;
    • Don't let anyone smoke around you or your children; and
    • Work or go to school in a smoke-free environment

    MEDICATIONS: A CLOSER LOOK AT CONTROL

     

    The ideal asthma controller is avoidance of triggers. Learning to avoid them will, in the long run, minimize symptoms and the need for medication. On the other hand, medication should never be used as a way to cover up symptoms, for instance, to keep the cat.
    Unfortunately, total avoidance of triggers is not always possible. Since you have to breathe, you're likely to end up with some inflammation. With some unusual exceptions, this means medication will have to be part of having well-controlled asthma, even in mild cases.

    CONTROLLERS

    The most important asthma medication is an anti-inflammatory "Controller." When you take it daily as prescribed, you can control your asthma symptoms. Indeed, you may feel almost asthma-free.
    Here are some anti-inflammatory Controller-type drugs your doctor may prescribe:
    • non-steroidal inhaler;
    • low-dose inhaled steroid;
    • high-dose inhaled steroid;
    • steroid pill;
    • leukotriene receptor antagonist (LTRA) pill.
    Your pharmacist can be a good resource to help you understand the role of each type of asthma medication and how to use them.

    The Expanding Role of your Pharmacist

    Shoppers Drug Mart HEALTHWATCH® Pharmacists have been specially trained to help you better understand:
    • asthma and your asthma triggers;
    • the role of your medications and how to use them properly;
    • the need to use additional devices, such as spacers.
    In addition HEALTHWATCH® Pharmacists provide:
    • a personalized Asthma Plan;
    • instruction sheets on asthma devices; and
    • information and instruction sheets on Peak Flow Meters.

    RELIEVERS

    Your quick relief medication is meant to work in 1 to 3 minutes and last 4 to 6 hours. Your goal is tonot need it, at least not more than 3 times a week. As you increase anti-inflammatory Controller medication, your need for a Reliever will decrease.

    INHALED STEROIDS

    Inhaled steroids offer the best option for the initial anti-inflammatory treatment of asthma. The initial dose in adults is usually 400 mcg daily of Beclovent/Becloforte (beclomethasone) or its equivalent in Pulmicort (budesonide) or Flovent (fluticasone). Ask your doctor. One to two inhalations are usually taken morning and evening. In more severe asthma, higher doses may be required.
    The initial dose in children is usually 200 to 1,000 mcg daily of Beclovent/Becloforte (beclomethasone) or its equivalent in Pulmicort (budesonide) or Flovent (fluticasone). Ask your doctor. One to two inhalations are usually taken morning and evening. Higher doses are rarely required.

    SAFETY OF INHALED STEROIDS

    Children who consistently use high doses of Beclovent/ Becloforte (beclomethasone) or its equivalent in Pulmicort (budesonide) or Flovent (fluticasone) to maintain well-controlled asthma should:
    • always rinse and spit after using their inhaled steroid;
    • have their height measured regularly with a special instrument called a calibrated stadiometer; and
    • ask to be referred to a specialist for assessment.
    Adults who consistently use high doses of Becloforte (beclomethasone) or its equivalent in Pulmicort (budesonide) or Flovent (fluticasone) to maintain well-controlled asthma should:
    • always rinse and spit after using their inhaled steroid;
    • ask to be referred to a specialist for assessment;
    • have the pressure inside the eyeball checked on a regular basis, particularly if they have a family history of glaucoma; and
    • ask to be referred for a test to measure bone density, especially if there are other risk factors for osteoporosis.

    Add-On Medications

    If asthma is not adequately controlled with moderate doses of inhaled steroids, other "add-on" drugs may be tried. These include LTRAs including Accolate and Singulair (pill form), long-acting bronchodilating Controllers, such as Serevent (salmeterol), Advair (salmeteral / fluticasone combination) or Oxeze or Foradil (formoterol). Less often, theophylline (pills), ipratropium or nedocromil (inhalers) may be added.

    LEUKOTRIENE RECEPTOR ANTAGONISTS (LTRAs)

    The newest class of anti-inflammatory Controller drugs is called leukotriene receptor antagonists (LTRAs). They are not steroids and are not inhaled but are in are pill form. These drugs may be combined with inhaled steroids as a means of keeping the dose of steroids as low as possible. For patients who choose not to use low doses of inhaled steroids for whatever reason, these drugs can be used alone as the best possible choice among other anti-inflammatory Controller drug options.
    There are currently two LTRAs available in Canada. One is called Accolate (zafirlukast), which is available for patients 12 years and older and is prescribed as one tablet twice a day for day and nighttime control. The other is Singulair (montelukast), which is available for adults and children as young as 6 years of age and is prescribed as one tablet taken daily at bedtime.

    INHALING DRUGS

    Inhalation is the recommended way of using Relievers and steroid Controllers. These medications are available in an aerosol puffer (metered dose inhaler, MDI) or in a special device called a dry powder inhaler (DPI).
    For children under 5 years of age, aerosol puffers are recommended and must be used with a special tube and mask attachment called a spacer. The aerosol puffer, or MDI, remains a popular inhaler for children 6 and up and adults, with or without a spacer.
    The aerosol puffer, however, is changing. Inhalers contain a gas called chloroflurocarbon (or CFC) to help spray the medicine into your lungs. CFCs, while safe for you, harm the ozone layer, which protects us from the sun's burning rays.
    There is one CFC-free inhaler on the Canadian market, a Reliever medication (salbutamol) called Airomir. Since all aerosol puffers will become CFC-free in Canada by 2005, with a projected 60% phase-out of current MDI inhalers by 2001, CFC-free puffers are being prescribed increasingly over what you might be using now. Ask your doctor for a CFC-free version of your current salbutamol Reliever.
    Many people prefer the dry powder inhaler, which is already CFC-free. The action of breathing in with the inhaler in your mouth is how the medicine gets into the lungs. This kind of device may not be appropriate for children under 5 years of age because they may be unable to breathe in hard enough to actuate the drug.

    Action Plans

    Asthma is a variable disease. It can improve and worsen. Asthmatics need to learn to keep track of symptoms with a Peak Flow Meter so they can increase medication at the earliest sign of a flare-up, before asthma gets out of control.
    A Peak Flow Meter is a small blowing device. When your asthma flares, the meter readings drop. Your doctor's written Action Plan will indicate at what peak flow reading you should begin taking more Controller medication.

    ADJUSTING MEDICATIONS

    Once well-controlled asthma is achieved (need for Reliever 3 or fewer times per week), your inhaled steroid should be reduced to the lowest possible dose needed to maintain control.

    A Final Word

    This article is intended as a basis for questions for your doctor, pharmacist, asthma educator, discussions with family, friends, teachers and coworkers who need to better understand asthma and for the individual or caregiver to take steps toward better control of the asthma they're living with.
    You control the road to better health!

    Reference: http://aaia.ca/en/patients_guide_to_asthma_care.htm

    Food Allergy (video)

    The Food Allergy Action Plan by FAAN is available from the FAAN website. You may copy these documents and distribute them freely.

    Tips for managing food allergy (MJA, 2004):

    - Always carry an epineprine auto-injector (EAI)
    - Always read food labels
    - Ask questions about food preparation (be aware of the risk of cross-contamination)
    - No label/don't eat
    - No Epi/don't eat
    - Tell friends about a serious food allergy
    - Tell friends if feeling unwell, especially after eating



    Tuesday, March 24, 2015

    Tips For Managing Food Allergy!!!!! Golden Rules!!!


    Tips for managing food allergy (MJA, 2004):

    - Always carry an epineprine auto-injector (EAI)
    - Always read food labels
    - Ask questions about food preparation (be aware of the risk of cross-contamination)
    - No label/don't eat
    - No Epi/don't eat
    - Tell friends about a serious food allergy
    - Tell friends if feeling unwell, especially after eating